Mikrobiota Usus Dan Gut-Lung Axis Pada Penyakit Paru

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Abstract


Gut has a bidirectional connection with lung. This is often called the gut-lung axis. Most lung diseases have high morbidity, mortality and disability. This is due to the inflammatory process. This inflammatory process not only caused physiological changes in the lungs, but also caused pathological conditions in the gut. Likewise, if gut health is not maintained, causing intestinal dysbiosis, it also has the potential for translocation or expansion of bacteria from the intestine to other organs. Therefore, providing intervention to the gut to maintain the balance of gut microbiota has been shown to improve inflammatory status and lung disease susceptibility. The intervention given can be in the form of probiotics or prebiotics.


Keywords


Microbiota, Gut-Lung Axis, Prebiotic, Probiotik, Short Chain Fatty Acid

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References


Wisnivesky J, de-Torres JP. The Global Burden of Pulmonary Diseases: Most Prevalent Problems and Opportunities for Improvement. Ann Glob Health. 2019 Jan 22;85(1):1.

O’Dwyer DN, Dickson RP, Moore BB. The Lung Microbiome, Immunity, and the Pathogenesis of Chronic Lung Disease. J Immunol. 2016 Jun 15;196(12):4839–47.

2018 - The Human Gut Microbiota.pdf.

Koh A, De Vadder F, Kovatcheva-Datchary P, Bäckhed F. From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites. Cell. 2016 Jun;165(6):1332–45.

Wang J, Li F, Tian Z. Role of microbiota on lung homeostasis and diseases. Sci China Life Sci. 2017 Dec;60(12):1407–15.

Dumas A, Bernard L, Poquet Y, Lugo-Villarino G, Neyrolles O. The role of the lung microbiota and the gut-lung axis in respiratory infectious diseases. Cell Microbiol. 2018 Dec;20(12):e12966.

Cervantes J, Hong B. The gut–lung axis in tuberculosis. Pathog Dis [Internet]. 2017 Nov 30 [cited 2019 Sep 19];75(8). Available from: http://academic.oup.com/femspd/article/doi/10.1093/femspd/ftx097/4082730

Butel M-J. Probiotics, gut microbiota and health. Médecine Mal Infect. 2014 Jan;44(1):1–8.

Bingula R, Filaire M, Radosevic-Robin N, Bey M, Berthon J-Y, Bernalier-Donadille A, et al. Desired Turbulence? Gut-Lung Axis, Immunity, and Lung Cancer. J Oncol. 2017;2017:1–15.

Frati F, Salvatori C, Incorvaia C, Bellucci A, Di Cara G, Marcucci F, et al. The Role of the Microbiome in Asthma: The Gut–Lung Axis. Int J Mol Sci. 2018 Dec 30;20(1):123.

Zou X-L, Wu J-J, Ye H-X, Feng D-Y, Meng P, Yang H-L, et al. Associations Between Gut Microbiota and Asthma Endotypes: A Cross-Sectional Study in South China Based on Patients with Newly Diagnosed Asthma. J Asthma Allergy. 2021 Aug;Volume 14:981–92.

Cait A, Hughes MR, Antignano F, Cait J, Dimitriu PA, Maas KR, et al. Microbiome-driven allergic lung inflammation is ameliorated by short-chain fatty acids. Mucosal Immunol. 2018 May;11(3):785–95.

Suprapti B, Suharjono S, Raising R, Yulistiani Y, Izzah Z, Nilamsari WP, et al. Effects of Probiotics and Vitamin B Supplementation on IFN-γ and IL-12 Levels During Intensive Phase Treatment of Tuberculosis. Indones J Pharm. 2018 Jun 22;29(2):80.

Lachmandas E, Boutens L, Ratter JM, Hijmans A, Hooiveld GJ, Joosten LAB, et al. Microbial stimulation of different Toll-like receptor signalling pathways induces diverse metabolic programmes in human monocytes. Nat Microbiol. 2017 Mar;2(3):16246.

Hu Y, Feng Y, Wu J, Liu F, Zhang Z, Hao Y, et al. The Gut Microbiome Signatures Discriminate Healthy From Pulmonary Tuberculosis Patients. Front Cell Infect Microbiol. 2019 Apr 3;9:90.

Zhang D, Li S, Wang N, Tan H-Y, Zhang Z, Feng Y. The Cross-Talk Between Gut Microbiota and Lungs in Common Lung Diseases. Front Microbiol. 2020 Feb 25;11:301.




DOI: http://dx.doi.org/10.30596%2Fjih.v2i2.9320

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