Perbedaan Efektivitas Ekstrak Hiji Pala (Myristica Fragnas Houtt) Dengan DIazepam Berdasarkan Durasi Tidur Mencit Swiss Webster

Abstract

Abstract: According to National Sleep Foundation in America, more than one
third (36%) in young adults aged 18-29 years old reported hard to wake up in the
morning. Nutmeg seeds contain atsiri oil about 10% and miristin that have
sedative effect. The purpose of this study is to prove that nutmeg seeds shorten
sleep induction time and prolong sleep time. This type of research is experimental
research with a post test only control group design. The samples used were 27
male Swiss Webster mice, which were divided into three groups. The first control
group was given diazepam; the second group was given nutmeg seed extract dose
of 7.5 mg; and the third group was given aquabides. The data obtained from the
sleep duration of mice in each group. To determine differences in each
experimental group, data with normal distribution were analyzed by one way
ANOVA test and data with abnormal distribution were analyzed by the KruskalWallis

test using SPSS 22.0 for Windows. The results of the Kruskal-Wallis test
showed that sleep induction time had a value of p = 0.001. Based on the one way
ANOVA test, the result shows the length of sleep time from the treatment group
has a significant difference to the control group with a value of p = 0,000 and
also showing a significant result to the comparison group with a value of p =
0,000. Nutmeg seed extract (Myristica fragrans Houtt.) with a dose of 7.5 mg can
significantly extend the sleep duration of mice.
Keywords: nutmeg seeds extract, sleep duration.