ASSOCIATION OF PPAR? INTRON 7 G/C (RS4253778) POLYMORPHISMS WITH MUSCULAR ENDURANCE AMONG SOCCER SCHOOL STUDENTS IN MEDAN

Abstract

Peroxisome proliferator-activated receptor alpha (PPAR?) is the transcription factor gene that regulates lipid metabolism and glucose homeostasis of energy within the mitochondria. PPAR? gene Intron 7 variation is associated with the phenotype of human performance. Homozygous GG is more often found among athletes concerning muscular endurance. This study aims to investigate the associationof PPAR? polymorphism with muscular endurance. Samples from buccalcells were collected from 77 boys (aged 11-16 years). PPAR? Intron 7 polymorphismwas examined using PCR-RFLP with restriction enzyme TaqI. Meanwhile, the Curl-Up test has been performed to determine the muscular enduranceof the subjects. The relationship between PPAR? Intron 7 polymorphismwith muscular endurance was assessed by using Fishers Exact test. The study found the genotype GG and GC of 97.4% and 2.6%, respectively. Muscularendurance was shown among categories of poor (66.2%) and fair (15.6%). Statistical analysis established no association between PPAR? polymorphismwith muscular endurance (p = 0,564).
Keywords: PPAR? polymorphisms, muscular endurance, Curl-Up test