Micronutrient Supplementation Therapy in Subfertile Men: A Systematic Study

Aidil Akbar


In Indonesia, the infertility rate reaches 16% of couples of childbearing age, and 50% of cases are caused by male reproductive disorders. In the current study, micronutrient substitution therapy can increase sperm count and motility in subfertile men but has not shown consistent results. This study is a systematic study that aims to determine the effectiveness of micronutrient supplementation therapy for subfertile cases and what micronutrients are used for subfertile therapy. A literature search was carried out using the Google Scholar application with the keywords supplementation therapy in subfertile, from the results of a literature search using the prism method, 18 articles were found that included in the inclusion criteria, and it was found that almost all articles stated that micronutrition supplementation therapy in subfertile patients showed improved results. the number and motility of sperm cells and the micronutrients that are widely used are zinc, carnitine, Co-Q10, Vitamin E, Vitamin C, Selenium, Vitamin B12. It can be concluded that micronutrient supplementation can improve the number of live sperm cells and sperm motility.


Sub fertile, micronutrients

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Garolla A, Petre GC, Francini-pesenti F, et al. Dietary Supplements for Male Infertility : A Critical Evaluation of Their Composition. :1-15.

Ahmadi S, Bashiri R, Ghadiri-anari A, Nadjarzadeh MDA. Antioxidant supplements and semen parameters: An evidence-based review. 2016;14(12):729-736.

Mumford SL, Johnstone E, Kim K, et al. A Prospective Cohort Study to Evaluate the Impact of Diet, Exercise, and Lifestyle on Fertility : Design and Baseline Characteristics. 2020;189(11):1254-1265. doi:10.1093/aje/kwaa073

Harzif AK, Prana V, Santawi A, Wijaya S. Discrepancy in perception of infertility and attitude towards treatment options : Indonesian urban and rural area. Published online 2019:1-7.

Kumar N, Singh AK. Role of Zinc in Male Infertility : Review of Literature. 2016;3(2):167-171. doi:10.5958/2394-2754.2016.00028.X

Zhao J, Dong X, Hu X, et al. Zinc levels in seminal plasma and their correlation with male infertility : A systematic review and. Nat Publ Gr. 2016;(February):1-10. doi:10.1038/srep22386

Alahmar AT. Effect of Vitamin C , Vitamin E , Zinc , Selenium , and Coenzyme Q10 in Infertile Men with Idiopathic Oligoasthenozoospermia. 2018;(March). doi:10.5005/jp-journals-10016-1147

Suliga E. The relationship between diet , energy balance and fertility in men. 2019;2018.

Majzoub A, Arafa M, Mahdi M, Agarwal A, Al K, Elbardisi H. Oxidation – reduction potential and sperm DNA fragmentation , and their associations with sperm morphological anomalies amongst fertile and infertile men. Arab J Urol. 2018;16(1):87-95. doi:10.1016/j.aju.2017.11.014

Canepa P, Lago ADAL, Leo CDE, et al. Combined treatment with myo-inositol , alpha-lipoic acid , folic acid and vitamins significantly improves sperm parameters of sub-fertile men : a multi-centric study. Published online 2018:7078-7085.

Jahan RS, Ishrat S, Bashar RS, Hossain M, Akter S. Zinc and Folate Supplement Improves Semen Quality : A Prospective Study in Subfertile Males. 2021;8235:136-142. doi:10.36348/sijog.2021.v04i04.010

Zhaku V, Beadini S, Beadini N. Combination of Maca , Korean ginseng extract and antioxidant therapy for male with oligoasthenozoospermia : Case study COMBINATION OF MACA , KOREAN GINSENG EXTRACT AND ANTIOXIDANT THERAPY FOR MALE WITH OLIGOASTHENOZOOSPERMIA : CASE STUDY. 2019;(March).

Terai K, Horie S, Fukuhara S, Miyagawa Y, Kobayashi K, Tsujimura A. Combination therapy with antioxidants improves total motile sperm counts : A Preliminary Study. 2020;(October 2019):89-94. doi:10.1002/rmb2.12308

Sharifzadeh F, Norouzi S, Ashrafi M, Aminimoghaddam S, Koohpayezadeh J. or re ct Pr oo. 2017;(July 2016). doi:10.17795/ojcr-7242

Salim H, Saeed M, Pharmacology C, et al. Using Zinc in Management of Subfertile Male Patients: a Clinical Trial. 2017;13(1):32-38.

Santos HO, Teixeira FJ. Use of medicinal doses of zinc as a safe and efficient coadjutant in the treatment of male hypogonadism. Aging Male. 2021;23(5):669-678. doi:10.1080/13685538.2019.1573220

Kasperczyk A, Dobrakowski M, Czuba ZP, Kapka-skrzypczak L. Environmental exposure to zinc and copper influences sperm quality in fertile males. 2016;23(1):138-143. doi:10.5604/12321966.1196869

Liu YL, Zhang MN, Tong GY, et al. The effectiveness of zinc supplementation in men with isolated hypogonadotropic hypogonadism. 2017;(July 2016):280-285. doi:10.4103/1008-682X.189621

Kopets R, Kuibida I, Chernyavska I, et al. Dietary supplementation with a novel l -carnitine multi-micronutrient in idiopathic male subfertility involving oligo- , astheno- , teratozoospermia : A randomized clinical study. 2020;(January):1-10. doi:10.1111/andr.12805

Salas-huetos A, Rosique-esteban N, Becerra-tomás N, Vizmanos B, Bulló M, Salas-salvadó J. The Effect of Nutrients and Dietary Supplements on Sperm Quality Parameters : A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Published online 2018:833-848. doi:10.1093/advances/nmy057

Khaw SC, Khaw SC, Wong ZZ, Anderson RA, Martins S. l -carnitine and l -acetylcarnitine supplementation for idiopathic male infertility. Published online 2020:67-81.

A M, A V, M T, et al. Importance of zinc concentration in seminal fluid of men diagnosed with infertility. Act Clin Croat. 2020;59(1):154-160. doi:10.20471/aac.2020.59.01.19

Mustafa G, Khan H, Butt MS, Nisa NU. Effectiveness of zinc administration in asthenospermia in infertile patients. 2020;45(1):1-4.

Alsalman ARS, Ph D, Almashhedy LA, et al. Effect of Zinc Supplementation on Urate Pathway Enzymes in Spermatozoa and Seminal Plasma of Iraqi Asthenozoospermic Patients : A Randomized Clinical Trial. 2020;13(4):315-323. doi:10.22074/ijfs.2020.5760.This

Vickram S, Rohini K, Srinivasan S, et al. Role of Zinc ( Zn ) in Human Reproduction : A Journey from Initial Spermatogenesis to Childbirth. Published online 2021:1-17.

Knez M, Nikolic M, Zekovic M, Stangoulis JC, Gurinovic M, Glibetic M. The influence of food consumption and socio-economic factors on the relationship between zinc and iron intake and status in a healthy population. Published online 2021. doi:10.1017/S1368980017001240

Alahmar AT. The impact of two doses of coenzyme Q10 on semen parameters and antioxidant status in men with idiopathic oligoasthenoteratozoospermia. Clin Exp Reprod Med. 2019;46(3):112-118. doi:10.5653/cerm.2019.00136

Bolle P, Evandri MG, Saso L. The controversial efficacy of vitamin E for human male infertility. Contraception. 2002;65(4):313-315. doi:10.1016/S0010-7824(02)00277-9

Corresponding A. The Relationship of Vitamin E to the Fertility in Men Aseel N.S.Ali. 2021;25(6):9441-9450.

Prasad SV, Bb G, Bb N. Role of Oxidative Stress and Vitamin C, E on Male Fertility: Mini Review. Int J Biomed Allied Heal Res. 2017;(December). www.ijbahr.com

Micic S, Lacic N, D D, et al. Double-blind, randomised, placebo-controlled trial on the effect of L-carnitine and L-acetylcarnitine on sperm parameters in men with idiopathic oligoazthenozoospermia. Andrologia. 2019;51(e13267):1-9. https://doi.org/10.1111/and.13267

Banihani SA. Vitamin B12 and semen quality. Biomolecules. 2017;7(2). doi:10.3390/biom7020042

Majzoub A, Agarwal A. Systematic review of antioxidant types and doses in male infertility : Benefits on semen parameters , advanced sperm function , assisted reproduction and live-birth rate. Arab J Urol. 2018;16(1):113-124. doi:10.1016/j.aju.2017.11.013

DOI: http://dx.doi.org/10.30596%2Fbf.v6i3.8920


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