Multiple Primary Cancer Diagnostic and Theurapetic Challenges: Vaginal Cancer with Cervical Cancer
Multiple primary cancer is diagnosed if multiple cancerous lesions appear in one or more organs in a person either simultaneously or at different times. Differentiating it from metastases, or recurrent cancer is a difficulty and a challenge that must be faced considering that the prognosis of multiple primary cancers is considered to be better if diagnosed correctly. Vaginal cancer is the second primary that should be considered in cervical cancer patients, especially those who have undergone radiation therapy. Treatment of multiple vaginal cancer with cervical cancer is very dependent on the individual considering the limited number of cases is still a limitation in the treatment of these patients, with various therapies in the form of radiation, a combination of surgery with radiation, chemotherapy, and a combination of surgery with chemotherapy.
Mesmoudi M, et.al., Triple malignancy in a single patient including cervical carcinoma, a basal cell carcinoma of the skin and a neuroendocrine carcinoma from an unknown primary site : A case report and review of the literature. Case Report. Journal of Medical Case Reports. 2011; 5: 462.
Senkus E, et al., Second lower genital tract squamous cell carcinoma following cervical cancer. Acta Obstet Gynecol Sacnd. 2000;79:765-70
Howe HL. A Review of the Definition for Multiple Primary Cancers in the United States. North American Association of Central Cancer Registries. Woorkshoop Proceedings in New Jersey, 2002: 2-37
Park JW, Park YK, Kim JS. A case of multiple primary malignancies following radiotherapy for adenosquamous cell carcinoma of the cervix. Case Report. Korean J Obstet Gynecol. 2012; 55 (12): 1026-30.
Mehdi I, et al. Synchronous and Metachronous Malignant Tumours expect the un-expected. J Pak Med Assoc. 2010, Vol. 60, No.11:905-9
Eser S, et al., Synchronous Primary Cancers of the Female Reproductive Tract in Turkish Women. Asian pasific J Cancer Prev. 2011; 12:857-9.
Bidus MA, Elkas JC. Cervical and Vaginal Cancer. Berek & Novak's Gynecology, Lippincott Williams & Wilkins. 14th Edition. 2007;31.: 1232-7
Nemejcova K, et al., Primary vaginal squamous cell carcinoma arising in a squamous inclusion cyst: Case report. Cesk Patol. 2012; 48(3): 153–5
Hacker FN. Vaginal Cancer. Berek and Hacker's Gynecologic Oncology, Lippincott Williams & Wilkins.; 5th Edition. 2010;14: 576-83
Choo YC, Anderson DG. Neoplasma of the Vagina Following Cervical Carcinoma. Gynecologic Oncology 1982; 14: 125-32
Coughlan C, et al., Vaginal cytology following primary hysterectomy for cervical cancer: Is it useful? Irish Journal Of Medical Science. 2006; 175:1
Alonso, et al., Human papillomavirus as a favorable prognostic biomarker in squamous cell carcinomas of the vagina. Gynecol Oncol. 2012; 125:194–9.
Insinga RP, Liaw KL, Johnson LG, A Systematic Review of the Prevalence and Attribution of Human Papillomavirus Types among Cervical, Vaginal, and Vulvar Precancers and Cancers in the United States. Cancer Epidemiol Biomarkers Prev. 2008;17:1611-22
Larsson, et al., Prognostic impact of human papilloma virus (HPV) genotyping and HPV-16 subtyping in vaginal carcinoma. Gynecologic Oncology. 2013;129:406–11
Sinno K, et al., Human papillomavirus genotype prevalence in invasive vaginal cancer from a registry-based population. J Obstet Gynecol. 2014 Apr;123(4):817-21
Hellman, et al., Human papillomavirus, p16INK4A, and Ki-67 in relation to clinicopathological variables and survival in primary carcinoma of the vagina. British Journal of Cancer. 2014;110:1561-70
Chaturvedi et al., Second Cancers After Squamous Cell Carcinoma and Adenocarcinoma of the Cervix. J Clin Oncol. 2009;27:967-973
Matylevich OP, Trukhan HV, Zubets OL, Mavrichev SA. Twenty years’ experience of primary vaginal cancer treatment at one cancer centre: does residence status matter?. ecancer 2021, 15:1267
Chai W, et al., Multiple Primary Cancer in Female Genital System. Medicine. 2017; 96:47
Liang S, et al., Three primary synchronous malignancies of the uterus, cervix, and fallopian tube. Medicine. 2018;97:24
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