Ko Infeksi Human Immunodeficiency Virus dengan Sifilis

Riri Arisanty Syafrin Lubis

Abstract


Abstrak: Sifilis adalah salah satu penyakit infeksi menular seksual yang disebabkan oleh Treponema pallidum, penularan dapat terjadi melalui kontak seksual dan darah serta dapat terjadi bersamaan dengan infeksi HIV. Dilaporkan suatu kasus sifilis pada seorang pria berumur 29 tahun yang sebelumnya telah terdiagnosis HIV dua tahun lalu. Pasien mengeluhkan  timbulnya bercak merah pada kedua telapak tangan sejak 1 bulan terakhir. Hasil pemeriksaan laboratorium VDLR menunjukkan 1:129 dan TPHA 1:1280. Pasien mendapatkan terapi benzyl penisilin 2,4 juta unit dosis tunggal secara intramuskuler dan tetap mengonsumsi obat anti retroviral. Hasil pengamatan pada hari ke 60 didapatkan perbaikan secara klinis dan laboratoris.


Keywords


Chancre, ko infeksi HIV sifilis, Treponema pallidum, TPHA, VDLR.

Full Text:

PDF

References


Ren M, Dashwood T, Walmsley S. The Intersection of HIV and Syphilis: Update on the Key Considerations in Testing and Management. Curr HIV/AIDS Rep. 2021;18(4):280-288. doi:10.1007/s11904-021-00564-z

Romeis E, Tantalo L, Lieberman N, Phung Q, Greninger A, Giacani L. Genetic engineering of Treponema pallidum subsp. Pallidum, the Syphilis Spirochete. PLoS Pathog. 2021;17(7):1-25. doi:10.1371/journal.ppat.1009612

Mongkaren M, Supit ASR, Mintjelungan CN, Bernadus JBB. Oral Manifestation of Sexual Transmitted Diseases. e-GiGi. 2022;10(2):221. doi:10.35790/eg.v10i2.41029

Anjaneyan G, Kumar A, Thomas J. Masson-Fontana stain: A silver lining for diagnosis of primary syphilitic chancre. Indian J Dermatol Venereol Leprol. 2022;88(6):822-824. doi:10.25259/IJDVL_581_2021

McIntosh EDG. Development of vaccines against the sexually transmitted infections gonorrhoea, syphilis, Chlamydia, herpes simplex virus, human immunodeficiency virus and Zika virus. Ther Adv Vaccines Immunother. 2020;8:1-14. doi:10.1177/2515135520923887

Park IU, Tran A, Pereira L, Fakile Y. Sensitivity and Specificity of Treponemal-specific Tests for the Diagnosis of Syphilis. Clin Infect Dis. 2020;71(Suppl 1):S13-S20. doi:10.1093/cid/ciaa349

Zhou C, Zhang X, Zhang W, Duan J, Zhao F. PCR detection for syphilis diagnosis: Status and prospects. J Clin Lab Anal. 2019;33(5). doi:10.1002/jcla.22890

Cornelisse VJ, Chow EPF, Latimer RL, et al. Getting to the bottom of it: Sexual positioning and stage of syphilis at diagnosis, and implications for syphilis screening. Clin Infect Dis. 2020;71(2):318-322. doi:10.1093/cid/ciz802

Lau A, Kong FYS, Fairley CK, et al. Azithromycin or Doxycycline for Asymptomatic Rectal Chlamydia trachomatis . N Engl J Med. 2021;384(25):2418-2427. doi:10.1056/nejmoa2031631

Chow EPF, Fairley CK. The role of saliva in gonorrhoea and chlamydia transmission to extragenital sites among men who have sex with men: new insights into transmission. J Int AIDS Soc. 2019;22(S6):33-35. doi:10.1002/jia2.25354

Vaillant J, A A, Gulick, G P. HIV Disease Current Practice. StatPearls. Published online 2022.

Tsuboi M, Evans J, Davies EP, et al. Prevalence of syphilis among men who have sex with men: a global systematic review and meta-analysis from 2000–20. Lancet Glob Heal. 2021;9(8):e1110-e1118. doi:10.1016/S2214-109X(21)00221-7

Middelveen MJ, Martinez RM, Fesler MC, et al. Classification and staging of morgellons disease: Lessons from syphilis. Clin Cosmet Investig Dermatol. 2020;13:145-164. doi:10.2147/CCID.S239840

Mahmud S, Mohsin M, Muyeed A, Islam MM, Hossain S, Islam A. Prevalence of HIV and syphilis and their co-infection among men having sex with men in Asia: A systematic review and meta-analysis. Heliyon. 2023;9(3):e13947. doi:10.1016/j.heliyon.2023.e13947

Wu Y, Zhu W, Sun C, et al. Prevalence of syphilis among people living with HIV and its implication for enhanced coinfection monitoring and management in China: A meta-analysis. Front Public Heal. 2022;10. doi:10.3389/fpubh.2022.1002342

Karimzadeh H, Kiraithe MM, Oberhardt V, et al. Mutations in Hepatitis D Virus Allow It to Escape Detection by CD8+ T Cells and Evolve at the Population Level. Gastroenterology. 2019;156(6):1820-1833. doi:10.1053/j.gastro.2019.02.003

Fan L, Yu A, Zhang D, Wang Z, Ma P. Consequences of HIV/syphilis co-infection on HIV viral load and immune response to antiretroviral therapy. Infect Drug Resist. 2021;14:2851-2862. doi:10.2147/IDR.S320648

Ong JJ, Baggaley RC, Wi TE, et al. Global Epidemiologic Characteristics of Sexually Transmitted Infections among Individuals Using Preexposure Prophylaxis for the Prevention of HIV Infection: A Systematic Review and Meta-analysis. JAMA Netw Open. 2019;2(12):1-16. doi:10.1001/jamanetworkopen.2019.17134

Park IU, Fakile YF, Chow JM, et al. Performance of Treponemal Tests for the Diagnosis of Syphilis. Clin Infect Dis. 2019;68(6):913-918. doi:10.1093/cid/ciy558

Hughes K, Chang J, Stadtler H, Wyatt C, Klotman M, Blasi M. HIV-1 infection of the kidney: Mechanisms and implications. Aids. 2021;35(3):359-367. doi:10.1097/QAD.0000000000002753

Polansky A, Levy I, Mor Z. Risk factors of syphilis co-infection among HIV-infected men who have sex with men in Tel-Aviv, Israel. AIDS Care - Psychol Socio-Medical Asp AIDS/HIV. 2019;31(9):1157-1161. doi:10.1080/09540121.2019.1612006

Wu MY, Gong HZ, Hu KR, Zheng HY, Wan X, Li J. Effect of syphilis infection on HIV acquisition: A systematic review and meta-analysis. Sex Transm Infect. 2021;97(7):525-533. doi:10.1136/sextrans-2020-054706

Fatima R, Arif T, Sami M. Isolated Palmar Rash as the Presentation of Secondary Syphilis: Syphilis Continues to Fascinate Physicians. Turkiye Klin Dermatoloji. 2022;32(2):128-130. doi:10.5336/DERMATO.2021-87455

Balagula Y, Mattei PL, Wisco OJ, Erdag G, Chien AL. The great imitator revisited: The spectrum of atypical cutaneous manifestations of secondary syphilis. Int J Dermatol. 2014;53(12):1434-1441. doi:10.1111/ijd.12518

Makanjuola BO, Maltecca C, Miglior F, Marras G, ... Identification of unique ROH regions with unfavorable effects on production and fertility traits in Canadian Holsteins. Genet Sel …. Published online 2021. doi:10.1186/s12711-021-00660-z

Fadhilah FR, Pakpahan SE, Rifa Atika, Nada Reliani. EVALUASI PEMERIKSAAN Treponema pallidum RAPID (TP-RAPID) dan Treponema Pallidum Haemagglutination Assay (TPHA) PADA KELOMPOK WANITA PEKERJA SEKS DI KOTA BANDUNG. J Indones Med Lab Sci. 2023;4(1):59-69. doi:10.53699/joimedlabs.v4i1.110

Benzathine Benzylpenicillin: A newly investigated pharmacokinetic profile in Japanese healthy participants, for essential drug against syphilis. 2017;1:608.

Nieuwenburg S, Rietbergen N, Van Zuylen D, Vergunst C, De Vries H. Erroneous treatment of syphilis with benzyl penicillin in an era with benzathine benzylpenicillin shortages. Sex Transm Infect. 2020;96(7):552. doi:10.1136/sextrans-2019-054380

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID- 19 . The COVID-19 resource centre is hosted on Elsevier Connect , the company ’ s public news and information . 2020;(January):2020-2022.

Liwan MA, Taufik SS, Eka HB, Amin S. Benzathine penicillin G intramuscular succesful treatment of ocular syphilis with human immunodeficiency virus positive: A case report. J Oftalmol. 2020;2(2):15-19.




DOI: https://doi.org/10.30596/jph.v4i4.16959

DOI (PDF): https://doi.org/10.30596/jph.v4i4.16959.g10213

Refbacks

  • There are currently no refbacks.


Alamat Pengelola: Gedung Kampus 1 Universitas Muhammadiyah Sumatera Utara (UMSU) Lantai II, Laboratorium Farmakologi dan Terapi Fakultas Kedokteran UMSU Jalan Gedung Arca No. 53 Medan Sumatera Utara Indonesia, Kode Pos 20217.

Kontak (WA): 0812-6208-2844

E-mail: jurnalpanduhusada@umsu.ac.id