Evaluation Of The Quality Of Packed Red Cell (PRC) In the Blood Donation Unit (BDU) Of The Indonesian Red Cross (IRC) Of Banda Aceh City: Haemolysis Rate As An Indicator Of A Good Quality Control Process
Abstract
Abstract: PRC is the most commonly used component of blood. This blood component comes from whole blood which then goes through a centrifugation process to separate into PRC blood components. In this separation process, it is not uncommon to cause haemolysis, which in the end PRC blood products do not provide a therapeutic effect for recipients. This study will look at the percentage of haemolysis that occurs during separation and whether it is still up to standard. This study aims to determine the risk of haemolysis in the processing of PRC blood products stored for 30 days at BDU of IRC of Banda Aceh City. Research benefits are knowing the risk of haemolysis in the processing of PRC blood products stored for 30 days at BDU IRC Banda Aceh City. This study used the cross-sectional method. The samples in this study amounted to 95 donor blood samples taken from blood bags with a shelf life of 30 days. Techniques sample sampling using a total sampling technique. Samples will be examined quantitatively with a value of the percentage of haemolysis of the blood sample. The samples test will be seen whether haemolysis occurs (<0.8%) or not/non-haemolysis (>0.8%) automatically using the HemoCue Plasma/Low tool. Of the 95 samples tested, 7.3% (7) of the samples were haemolyzed and 92.8% (88) samples did not have haemolysis. This study showed that the majority of samples did not have haemolysis with a percentage of 92.8% and those with haemolysis were only 7.3%. This shows that the quality of blood services at BDU of IRC of Banda Aceh City is still by Peraturan Menteri Kesehatan (PMK) or regulation of the minister of health standard No. 91 yr. 2015 with the percentage of samples that do not undergo haemolysis above 75%.
Keywords
Full Text:
PDFReferences
Rosalinda, Andi. Gambaran tumbuh kembang anak dengan thalassemia major (studi pustaka). Dalam Moeslichan S. Darah dan tumbuh kembang.2022.UNS. https://erepository.uwks.ac.id/11904/1/Abstrak.pdf
Unit Donor Darah IRC Pusat. Pedoman pelayanan transfusi darah. Kegiatan unit transfuse darah penanganan donor dan kepuasan pelanggan. Unit Donor Darah. Edisi kelima. 2020.
AABB. Technical manual. in: Brecher ME, editor Pretransfusion testing: Res cell antigen-antibody reaction and their detection. 28th ed; United States: AABB. 2018.
European Committee (Partial Agreement) on Blood Transfusion (CD-P-TS).In : EDQM Allee Kastner editor. Guide to Preparation, Use and Quality Assurance of Blood components. 17th ed. Council of Europe. 2020; 249-262.
Xiao-yan, Xiao-ma Wu, Yang Zhao, Ect. In: Van der Meer P, Pietersz R, Hinloopen B, Dekker W, Reesink H. Automated separation of whole blood in top and bottom bags into components using the Compomat G4. International Journal of Hematology. 2022. 93(5):660-3
Saunderus WB. Transfusion Medicine Vol 18. In: Samuel O. Sowemimo-Coker, Red Blood Cell Haemolysis During Processing, 2019. pp46-60
MK Republik Indonesia, “Peraturan Menteri Kesehatan Republik Indonesia Nomor 91 Tahun 2015 Tentang Standar Pelayanan Transfusi Darah,” dalam Peraturan Menteri Kesehatan Republik Indonesia Nomor 91 Tahun 2015 Tentang Standar Pelayanan Transfusi Darah Dengan, 2015.
B. Pengawas et al., “Badan pengawas obat dan makanan republik indonesia,” hlm. 1–155, 2020.
Saunderus WB. Red Blood Cell Haemolysis During Processing. Transfusion medicine. 2018;16:46-60.
Hess JR, Sparrow RL, van der Meer PF, Acker JP, Cardigan RA, Devine DV. Red blood cell haemolysis during blood bank storage: using national quality management data to answer basic scientific questions. Transfusion. 2019;49: 2599-603.
Akbar, T. I. S . Potensi Hemolisis dan Kegunaan Klinis Produk Darah Washed Erythrocyte dan Leukodepleted. Monograph. Yayasan Daarul Huda. 2020; 1-15, ISBN : 978-623-96354-5-9
Buehler PW, D’Agnillo F. Toxicological consequences of extracellular haemoglobin: biochemical and physiological perspectives. Antioxid Redox Signal. 2019;12:275-91.
B. Pengawas et al., “Badan pengawas obat dan makanan republik indonesia,” pp. 1–155, 2020.
D. Orlov and K. Karkouti, “The pathophysiology and consequences of red blood cell storage,” Anaesthesia, vol. 70, pp. 29–37, 2019.
F. Oystein et al., Guide to the Preparation, Use and Quality Assurance of Blood Components.., 20th ed. 2020.
R. N. Makroo et al., “Evaluation of the red cell haemolysis in packed red cells during processing and storage,” Asian J. Transfus. Sci., vol.6, no. 1, pp. 15–17, Jan. 2019.
E. Gkoumassi, M. J. Dijkstra-Tiekstra, D. Hoentjen, and J. De Wildt- Eggen, “Haemolysis of red blood cells during processing and storage,” Transfusion, 2012.
C. Blasi Brugué et al., “In vitro quality control analysis after processing and during storage of feline packed red blood cells units,” BMC Vet. Res., vol. 14, no. 1, pp. 1–8, 2018.
E. Hussein and A. Enein, “Clinical and quality evaluation of red blood cell units collected via apheresis versus those obtained manually,” Lab. Med., vol. 45, no. 4, pp. 238–243, 2019.
P. R. Howard, BASIC & APPLIED CONCEPTS of BLOOD BANKING and TRANSFUSION PRACTICES, 4th ed. Florida: Elseiver, 2017.
A. Orbach, O. Zelig, S. Yedgar, and G. Barshtein, “Biophysical and Biochemical Markers of Red Blood Cell Fragility,” Transfus. Med. Chemotherapy, 2019.
DOI: https://doi.org/10.30596/bf.v8i1.12168
DOI (PDF): https://doi.org/10.30596/bf.v8i1.12168.g9248
Refbacks
- There are currently no refbacks.
JURNAL BULETIN FARMATERA
Gedung Kampus 1 Universitas Muhammadiyah Sumatera Utara (UMSU) Lantai II, Laboratorium Farmakologi dan Terapi Fakultas Kedokteran UMSU Jalan Gedung Arca No. 53 Medan Sumatera Utara Indonesia, Kode Pos 20217.
Contact (WA): 0812-6208-2844
E-mail: farmatera@umsu.ac.id
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.