Administration Of Aloe Vera Extract (Aloe Vera L.) Effectively Inhibits The Growth Of The Fungus Malassezia Furfur Causing The Occurrence Of Pythriaasis Versicolor In Vitro
Abstract
Abstract: Pytiriasis versichloror, or better known as panu, is a skin infection caused by a superficial fungus, Malassezia furfur. This disease causes skin discolouration, accompanied by itching in the infected area. Although not contagious, pityriasis versichloror occurs in adolescents or young adults, with risk factors including tropical climate, individual hygiene, environmental factors, age, sex, and genetic factors. Herbal plants, such as aloe vera (Aloe vera L.), have potential as an alternative treatment. Aloe vera has a wide variety of ingredients such as quinones, saponins, aminoglycosides, caffeine, tannins, salicylic acid, flavonoids, synaptic acid, essential oils, and sulfur, some of which have antifungal properties. Previous research has shown that aloe vera extract has an inhibitory effect on the growth of Malassezia furfur fungus. This study aims to determine the effectiveness of giving aloe vera extract (Aloe vera l.) on the growth of the fungus Malassezia furfur, which causes versichloror pityriasis in vitro. This study is an experimental research with a posttest-only control group design. Research shows that the administration of aloe vera extract has a positive impact on inhibiting the growth of Malassezia furfur fungus. Statistical analysis using the Mann-Whitney test confirmed that aloe vera extract effectively inhibited the growth of the fungus. The 90% concentration of aloe vera extract showed the best inhibition effect compared to the concentrations of 80% and 85%. This study shows that aloe vera extract has the potential as an antifungal agent to treat versicolor pityriasis. The 90% concentration of aloe vera extract showed the best inhibition effect, and these findings could be the basis for the development of new therapies in the treatment of versicolor pityriasis using aloe vera extract.
Keywords
Full Text:
PDFReferences
Mescher AL. Junqueira’s Basic Histology. 13th ed. 2018.
Sorrell RL, PD. Atlas of Human Histology: A Guide to Microscopic Structure of Cells, Tissues, and Organs. Published online 2008:1–363.
Heipni H. Review artikel: Pengaruh ekstrak bawang putih (Allium sativum L.) terhadap pertumbuhan jamur Malassezia furfur penyebab penyakit panu (Tinea versicolor). J Dunia Farm. 2021;5(1):46–53. doi:10.33085/jdf.v5i1.4761
Ariana D. Perbedaan zona hambat terhadap jamur Malassezia furfur antara pemberian ekstrak umbi bawang putih (Allium sativum Linn) dengan ekstrak kulit umbi bawang putih (Allium sativum Linn). J Muhammadiyah Med Lab Technol. 2018;1(2):77. doi:10.30651/jmlt.v1i2.1501
Chandra K, Ratih NLP, Karna V, Wiraguna AAGP, Denpasar S. Prevalensi dan karakteristik pityriasis versicolor di RSUP Sanglah Denpasar periode Januari 2017. Med Udayana. 2019;8(12):1–8.
Radilla W. Hubungan personal hygiene individu dengan kejadian pityriasis versicolor: sebuah tinjauan pustaka. J Med Hutama. 2022;3(2):1758–1763.
Agusrimansyah K, Soleha TU, Gita M U, Julii. Perbandingan efektivitas lidah buaya (Aloe vera) dan buah adas (Foeniculum vulgare) terhadap pertumbuhan Malassezia furfur. Medula. 2019;9(1):71.
Mayasari D. Perbandingan efektivitas terbinafin dengan ekstrak daun ketepeng cina (Cassia alata L.) terhadap pertumbuhan jamur (Malassezia furfur) sebagai etiologi pityriasis versicolor: the comparison of effectiveness terbinafin with leaves extract of Senna alata. J Agromedicine Unila. 2018;5(2):567–573.
Natalia D, Rahmayanti S, Nazaria R, Parasitologi D. Hubungan antara pengetahuan mengenai pitiriasis versicolor dan PHBS dengan kejadian pitiriasis versicolor pada santri Madrasah Tsanawiyah Pondok Pesantren X Kecamatan Mempawah Hilir. J CDK-260. 2018;45(1):7–10.
Marlina D. Gambaran karakteristik pitiriasis versicolor di poliklinik kulit dan kelamin. J Med Malahayati. 2016;3(4):165–170.
Saragih DMC, Rahmadani GS, Parhusip KR, Nasution PN, Tampubolon YMA. Seventh postgraduate bio expo 2022: realisasi strategi pembelajaran biologi berbasis ICT dengan penerapan kerangka kerja berbasis keterampilan abad 21. Proc Semin Nas VIII Biol dan Pembelajarannya. 2022:2–3.
Ariana D, Kunsah B, Agung YA. Daya hambat lendir Aloe vera Linn terhadap pertumbuhan Malassezia furfur secara in vitro. Sun. 2015;2(4):44–48.
Wijaya IKWAW, Masfufatun. Potensi lidah buaya (Aloe vera) sebagai antimikroba dalam menghambat pertumbuhan beberapa fungi: literature review. J Kedokt dan Kesehat. 2022;18(2):202–211. https://jurnal.umj.ac.id/index.php/JKK
Bhuvana K, Heima N, Rajesh P. Review on Aloe vera. Int J Adv Res. 2014;2(3):677–691. http://www.journalijar.com/uploads/464_IJAR-2927.pdf
In-vitro S. Karya tulis ilmiah: daya hambat lendir lidah buaya (Aloe vera Linn) terhadap pertumbuhan jamur Malassezia furfur. 2015.
DiFiore’s. Atlas of Histology with Functional Correlations. 2008. http://medcontent.metapress.com/index/A65RM03P4874243N.pdf
Guillot J, Bond R. Malassezia yeasts in veterinary dermatology: an updated overview. Front Cell Infect Microbiol. 2020;10:79. doi:10.3389/fcimb.2020.00079
Vijayakumar R, Muthukumar C, Kumar T, Saravanamuthu R. Characterization of Malassezia furfur and its control by using plant extracts. Indian J Dermatol. 2006;51(2):145–148. doi:10.4103/0019-5154.26942
Mathur M, Acharya P, Karki A, Nisha KC, Shah J. Dermoscopic pattern of pitiriasis versicolor. Clin Cosmet Investig Dermatol. 2019;12:303–309. doi:10.2147/CCID.S195166
Rakhmawati MD, Lumban Gaol TR, Kurniati ID. Aktivitas antifungi cuka nanas (Ananas comosus) pada pertumbuhan jamur Malassezia furfur. Biomeidika. 2022;14(2):136–146. doi:10.23917/biomeidika.v14i2.18564
Zahra M, Subchan P, Widodo A. Pengaruh perilaku higiene perorangan terhadap prevalensi terjadinya penyakit pitiriasis versicolor di panti asuhan Darul Yatim Demak. Diponegoro Med J. 2019;8(1):284–290.
Wang K, Cheng L, Li W, et al. Susceptibilities of Malassezia strains from pitiriasis versicolor, Malassezia folliculitis, and seborrheic dermatitis to antifungal drugs. Heliyon. 2020;6(6):e04203. doi:10.1016/j.heliyon.2020.e04203
Park M, Park S, Jung WH. Skin commensal fungus Malassezia and its lipases. J Microbiol Biotechnol. 2021;31(5):637–644. doi:10.4014/jmb.2012.12048
Saunte DM, Gaitanis G, Hay RJ. Malassezia-associated skin diseases, the use of diagnostics and treatment. Front Cell Infect Microbiol. 2020;10:112. doi:10.3389/fcimb.2020.00112
Januwarsih S, Assa F, Firdadiy, Munanda Putri N, Cahyono A. Pitiriasis versicolor. Continu Med Educ. 2022:349–358.
Partogi D. Pitiriasis versicolor dan diagnosis bandingnya (ruam-ruam bercak putih pada kulit). Res J Pharm Biol Chem Sci. 2008;5(4):12–21. http://www.scielo.br/pdf/abd/v86n4/en_v86n4a32.pdf
Goodman LS, Gilman A. Goodman & Gilman: Dasar Farmakologi Terapi. 2012.
Gupta AK, Foley KA. Antifungal treatment for pitiriasis versicolor. J Fungi. 2015;1(1):13–29. doi:10.3390/jof1010013
Tran Cam V, Van TN, Tran Hau K, et al. Efficacy of azole antifungal in treatment of pitiriasis versicolor. Open Access Maced J Med Sci. 2019;7(2):272–274. doi:10.3889/oamjms.2019.092
Meilliiawati R. Potensi tanaman lidah buaya (Aloe pubescens) dan keunikan kapang endofit yang berasal dari jaringannya. BioTrends. 2018;9(1):1–6.
Ramadhan AF, Sari M, Asmeidiana A. Efektivitas penambahan ekstrak kelopak bunga rosella (Hibiscus sabdariffa L) terhadap aktivitas antioksidan minuman lidah buaya (Aloe vera). Agroindustri Technol J. 2018;2(2):116. doi:10.21111/atj.v2i2.3788
Sianturi CY. Manfaat lidah buaya sebagai anti penuaan melalui aktivitas antioksidan. Essence Sci Med J. 2019;17(1):34–38.
Mukhtarini. Ekstraksi, pemisahan senyawa, dan identifikasi senyawa aktif. J Kesehat. 2014;VIII(2):361. doi:10.1007/s11293-018-9601-y
Huslina F. Pengaruh ekstrak daun lidah buaya (Aloe vera) terhadap pertumbuhan jamur Candida albicans secara in vitro. Biot J Ilm Biol Teknol dan Kependidikan. 2017;5(1):72. doi:10.22373/biotik.v5i1.2977
Mustarichiei R, Musfiroh I, Levita J. Metode penelitian tanaman obat. 2011.
Faris MA, Suparisno SS. Khasiat dan manfaat tanaman berkhasiat obat. 2015.
Kurniati E, Juswadah. Aktivitas anti-Malassezia dari ekstrak etanol dari lidah buaya (Aloe vera L). J Ilmu Kefarmasian Indonesia. 2014;12(1):55–60.
Guo X, Fu X, Hu G, Zhang Y. Anti-Malassezia furfur activity of Aloe vera gel extracts determined by an agar diffusion method. J Pure Appl Microbiol. 2016;10(1):503–507.
DOI (PDF): https://doi.org/10.30596/bf.v11i2.26963.g14404
Refbacks
- There are currently no refbacks.
JURNAL BULETIN FARMATERA
Gedung Kampus 1 Universitas Muhammadiyah Sumatera Utara (UMSU) Lantai II, Laboratorium Farmakologi dan Terapi Fakultas Kedokteran UMSU Jalan Gedung Arca No. 53 Medan Sumatera Utara Indonesia, Kode Pos 20217.
Contact (WA): 0812-6208-2844
E-mail: farmatera@umsu.ac.id

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

