Effect of Vitamin E Use on Hot Flash Reduction in Menopausal Women
Abstract
Abstract : Hot flash is a sudden hot sensation that usually appears in the chest, neck, and face, accompanied by sweating, heart palpitations, and can be triggered by a warm environment, hot drinks, or emotional stress. These symptoms are often the main reason women seek medical care during perimenopause because it can interfere with quality of life. Vitamin E, with its antioxidant properties, has been shown to be able to reduce the intensity and frequency of hot flashes through improved adrenal function. This study aims to assess the effect of Vitamin E administration on the reduction of hot flashes in menopausal women. The method used was an experiment with administering Vitamin E daily for four weeks to the study subjects. Data was obtained from a questionnaire of hot flash patients in 2022 at Bhayangkara Hospital Medan based on a doctor's examination and the HFRS scale. The results of the statistical test showed a P-Value of 0.000, lower than alpha 0.05, so the null hypothesis was rejected. In conclusion, Vitamin E is significantly effective in reducing hot flashes in menopausal women.
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Andrea C. Menopause Symptoms, Causes, Diagnosis, Treatment, and Coping. Published online 2022:2.
Menopause P. sp. irakusuma. Published online 2010:7–26.
Kimberly Peacock; Kari M. Ketvertis. Menopause peacock k - StatPearls - NCBI Bookshelf. Published online 2022.
Bansal R, Aggarwal N. Menopausal hot flashes: A concise review. J Midlife Health. 2019;10(1):6–13. doi:10.4103/jmh.JMH-7-19
Freedman RR. Pathophysiology and treatment of menopausal hot flashes. Semin Reprod Med. 2005;23(2):117–125. doi:10.1055/s-2005-869479
Tania Lugo ; Maggie Tetrokalashvili . Hot flashes - StatPearls - Rak Buku NCBI. Published online 2022.
Khatereh Ataei-Almanghadim 1 , Azizeh Farshbaf-Khalili 2 , Ali Reza Ostadrahimi 3 , Elnaz Shaseb 4 MM 5. Efek kapsul oral kurkumin dan vitamin E pada hot flashes dan kecemasan pada wanita pascamenopause Uji coba terkontrol acak tiga buta - ScienceDirect. Published online 2019.
Stuenkel CA, Davis SR, Gompel A, et al. Treatment of Symptoms of the Menopause : An Endocrine Society Clinical Practice Guideline. 2015;100(November):3975–4011. doi:10.1210/jc.2015-2236
Abedi MH 1 MTP. Effect of oral antioxidants supplement (Vitamin E and Omega3) on Frequency and Intensity of hot flashes in postmenopausal women. Published online 2015.
Zareai SZAKM. The Effect of Vitamin E on Hot flashes in Menopausal Women. Published online 2007:204–207. doi:10.1159/000106491
Stepan Feduniw,1 Lidia Korczyńska,2 Konrad Górski,2 Magdalena Zgliczyńska,3,* Monika Bączkowska,2 Maciej Byrczak,2 Jakub Kociuba,2 Mohamed Ali,4 5 and Michał Ciebiera2. The Effect of Vitamin E Supplementation in Postmenopausal Women—A Systematic Review - PMC. Published online 2022.
Ziaei S, Kazemnejad A, Zareai M. The effect of vitamin E on hot flashes in menopausal women. Gynecol Obstet Invest. 2007;64(4):204–207. doi:10.1159/000106491
Santoro N. Menopausal Symptoms and T h e i r Ma n a g e m e n t. Endocrinol Metab Clin NA. 2015;44(3):497–515. doi:10.1016/j.ecl.2015.05.001
Istiqhosah N. Kajian Asuhan Pada Menopause; Sebuah Strategi Untuk Meningkatkan Kualitas Hidup Menopause. Arh Hig Rada Toksikol. 2010;60(4):982–992. https://www.scopus.com/inward/record.uri?eid=2-s2.0-33645547325%7B&%7DpartnerID=40%7B&%7Dmd5=5c937a0c35f8be4ce16cb392381256da
R.thurstone. Gejala Vasomotor dan Menopause Temuan dari Studi Kesehatan Wanita di Seluruh Negeri - PMC. Published online 2012.
McLaren, H. C. (1949). Vitamin E in the Menopause. BMJ, 2(4641) 1378–1382. doi:10.1136/bmj.2.4641.1378. VITAMIN E IN THE MENOPAUSE *. 1949;(647):1378–1382.
e. listiana. effleure massage dan hot flashes. Published online 2020:11–28.
Rapkin AJ. Vasomotor symptoms in menopause : physiologic condition and central nervous system approaches to treatment. 2007;(February). doi:10.1016/j.ajog.2006.05.056
S.putri. pengaruh pendidikan kesehatan reproduksi terhadap pengetahuan dan sikap wanita pra-lansia dalam menghadapi masa menopause. 2023;2(4):750–758.
Institute N on aging. What Is Menopause National Institute on Aging. Published online 2021.
Prabayoni A. gambaran keluhan fisik dan psikologis wanita menopause pada masa pandemi covid-19 di wilayah kerja puskesmas bebandem tahun 2021. 2021;(2003):8–26.
Seritan AL, Iosif AM, Park JH, Deatheragehand D, Sweet RL, Gold EB. Self-reported anxiety, depressive, and vasomotor symptoms: A study of perimenopausal women presenting to a specialized midlife assessment center. Menopause. 2010;17(2):410–415. doi:10.1097/gme.0b013e3181bf5a62
Utari dr. R. sehatq dr reni. Published online 2021.
Lisa Gallicchio, Ph.D.,a,b,c Susan R. Miller, Sc.D.,d Judith Kiefer, M.S., R.N.,d Teresa Greene,d Howard A. Zacur, M.D., Ph.D.,d and Jodi A. Flaws PD. Risk factors for hot flashes among women undergoing the menopausal transition: baseline results from the Midlife Women’s Health Study. Published online 2015.
Phuong Khanh H. Morrow,corresponding author Danielle N. Mattair and GNH. Hot flashes A Review of Pathophysiology and Treatment Modalities - PMC. Published online 2011.
Amos P. Postmenopausal Hot Flushes Pathophysiology and Clinical Relevance to Cardiovascular Disease SpringerLink. Published online 2012.
Vered D, Lynda Ullmer R, Juan F Lopez M, Yolanda Smith M, Claudine Isaacs M, Daniel F Hayes M. Hot flushes - The Lancet. Published online 2002.
Tetrokalashvili. TLM. Hot flashes - StatPearls - NCBI Bookshelf. Published online 2021.
Chris Stubbs, MD (PGY-2), Lisa Mattingly, MD (PGY-3), Steven A. Crawford, MD, Elizabeth A. Wickersham, MD, Jessica L. Brockhaus, BA, and Laine H. McCarthy M. Do SSRIs and SNRIs reduce the frequency and/or severity of hot flashes in menopausal women. Published online 2017.
Kronenberg F, Fugh-Berman A. Complementary and alternative medicine for menopausal symptoms: A review of randomized, controlled trials. Ann Intern Med. 2002;137(10):805–813. doi:10.7326/0003-4819-137-10-200211190-00009
Handan Ozcan, 1 Pınar Çolak, 1 Berna Oturgan 2 and Esra Gülsever2. Complementary and alternative treatment methods for menopausal hot flashes used in Turkey - PMC. Published online 2019.
National Center for Biotechnology Information. Vitamin E | C29H50O2 - PubChem. Retrieved May 29, 2022. Published online 2022. https://pubchem.ncbi.nlm.nih.gov/compound/Vitamin-E
harvard univeristy. Vitamin E The Nutrition Source Harvard T. Published online 2023.
Maret G. Trabera,c * and Jan F. Stevens. Vitamins C and E Beneficial effects from a mechanistic perspective - PMC. Published online 2011.
Agarwal SBDA. Peran stres oksidatif pada menopause - PMC. Published online 2013.
Rezasoltani P, Elliyoun N, Ziaie T, Leyli EK, Aski K, Sobhani A. Effect of Vitamin E Supplementation on Plasma Nitric Oxide in Menopausal Women with Hot flashes : A Cross-Over , Randomized Clinical Trial. 2018;20(9). doi:10.5812/ircmj.68800.Research
DOI (PDF): https://doi.org/10.30596/bf.v12i1.27885.g15056
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JURNAL BULETIN FARMATERA
Gedung Kampus 1 Universitas Muhammadiyah Sumatera Utara (UMSU) Lantai II, Laboratorium Farmakologi dan Terapi Fakultas Kedokteran UMSU Jalan Gedung Arca No. 53 Medan Sumatera Utara Indonesia, Kode Pos 20217.
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