Effectiveness of Celery Leaf Extract Gel (Apium graveolens(Linn.) As A Treatment for IIa Degree Burn Wounds in Wistar White Rats (Rattus norvegicus) (In Vivo Study)

Abstract

Abstract: Indonesia is one of the countries that has traditionally used traditional medicine as a treatment. The pharmacological activity of celery leaves is antimicrobial, antibacterial, and anti-inflammatory. As one of the herbal ingredients, celery (Apium graveolens) has the potential to be developed as an anti-inflammatory drug because it contains the main compound apiin, which is the main metabolite for anti-inflammation. This study aims to determine the Effectiveness of Celery Leaf Extract Gel (Apium graveolens(Linn.) As a Treatment of Grade II Burns in White Wistar Rats (Rattus norvegicus) (In Vivo Study). This study is a true experimental study. 30 rats were divided into five groups, namely rats with grade IIA burns given sulfadiazine cream, negative control, celery gel preparations with concentrations of 1%, 2% and 4%; the average number of days of wound healing was tested with One-Way ANOVA. The average healing of grade IIA burns in the positive control group was 7.5 days, in the negative control 17.3 days, treatment I 13.6 days, treatment II 9.5 days, and treatment III 9.0 days. One-way ANOVA test value (p <0.05) showed significant differences among the treatment groups. Post hoc test showed no significant difference between the positive group and treatment group 3 (p=0.061). Conclusion: Celery gel (Apium graveolens) is effective in healing burns in grade IIA white Wistar rats at a dose of 4%.