Differences in Haemoglobin Levels Related to The Shelf Life of Packed Red Cells (PRC) on Day 1, Day 7 And Day 15 at UTD Pirngadi Medan
Abstract
Abstract: Packed red blood cells (PRC) are blood components separated from whole blood, consisting of red blood cells with most of the plasma, leukocytes, and platelets removed. Haemoglobin is the main protein in red blood cells responsible for transporting oxygen from the lungs throughout the body and carrying carbon dioxide back to the lungs for excretion. During storage, red blood cell membranes become more fragile due to oxidative stress and metabolic changes. Membrane damage can cause hemolysis, which is the rupture of red blood cells that release free haemoglobin into the storage solution. This study aims to determine the difference in HB levels with the shelf life of packed red cells (PRC) on haemoglobin levels on day 1, day 7 and day 15 at UTD Pirngadi Medan. This type of research is a prospective study; this study was conducted at various times for comparison. The total sample in this study was 75 people. Data analysis was processed using SPSS. First, a normality test was carried out; the normality test used was Kolmogorov-Smirnov. After the normality test, a homogeneity test was carried out. If the data are homogeneously/normally distributed, a One-Way ANOVA test is performed to compare. Results: There is a significant difference between haemoglobin levels on day 1, day 7, and day 15. The storage period of PRC can affect haemoglobin levels.
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DOI (PDF): https://doi.org/10.30596/bf.v12i2.30508.g15628
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JURNAL BULETIN FARMATERA
Gedung Kampus 1 Universitas Muhammadiyah Sumatera Utara (UMSU) Lantai II, Laboratorium Farmakologi dan Terapi Fakultas Kedokteran UMSU Jalan Gedung Arca No. 53 Medan Sumatera Utara Indonesia, Kode Pos 20217.
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E-mail: farmatera@umsu.ac.id
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