Application of Autologous Mesenchymal Stem Cells in Various Diseases: A Systematic Review
Abstract
Abstract:The use of mesenchymal stem cells (MSCs) to cure various diseases has become more widespread. Various clinical trials have been reported, both at level 1 and level 4. This systematic literature study aims to find out what diseases have been treated with autologous mesenchymal stem cells.This study is a systematic literature study by conducting literature searches in national and international journals in the last five years using the Google Scholar application using a systematic study method with the help of prism diagrams and classification tables to facilitate search.From the search results, 24 papers were obtained that were included in the inclusion criteria. The results of this study found that the use of MSCs as an alternative in the treatment of diseases has been very much carried out in clinical trials, where most of the results of these studies show a good level of safety, and can provide improvements histologically and physiologically, although in some diseases further research must be carried out to obtain consistent results.
Keywords: Mesenchymal Stem Cells, MSCs, Autologous
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Bhasin A, Ss K, Bhatia R, Mohanty S, Mvp S. Safety and Feasibility of Autologous Mesenchymal Stem Cell Transplantation in Chronic Stroke in Indian patients . A four-year follow up. 2017;13(1):14-19.
Block TJ, Marinkovic M, Tran ON, et al. Restoring the quantity and quality of elderly human mesenchymal stem cells for autologous cell-based therapies. Published online 2017:1-13. doi:10.1186/s13287-017-0688-x
Monselise RGCA, Negrini GBS. Stem cells therapy in acute myocardial infarction : a new era ? Clin Exp Med. 2021;21(2):231-237. doi:10.1007/s10238-021-00682-3
Centeno C, Markle J, Dodson E, et al. Treatment of lumbar degenerative disc disease ? associated radicular pain with culture ? expanded autologous mesenchymal stem cells : a pilot study on safety and efficacy. J Transl Med. Published online 2017:1-12. doi:10.1186/s12967-017-1300-y
Joshua M. Hare, MD, a, b Darcy L. DiFede, RN, BSN, a Angela C. Rieger, MD M, a Victoria Florea, MD A, Ana M. Landin, PHD, a Jill El-Khorazaty M, et al. Randomized Comparison of Allogeneic Versus Autologous Mesenchymal Stem Cells for Nonischemic Dilated Cardiomyopathy. J Am Coll Cardiol. 2017;69(5). doi:10.1016/j.jacc.2016.11.009
Jeong H, Yim HW, Park H, Cho Y. Mesenchymal Stem Cell Therapy for Ischemic Heart Disease : Systematic Review and Meta-analysis. 2018;11(1):1-12.
Zhu Y, Wang Y, Zhao B, et al. Comparison of exosomes secreted by induced pluripotent stem cell-derived mesenchymal stem cells and synovial membrane-derived mesenchymal stem cells for the treatment of osteoarthritis. Published online 2017:1-11. doi:10.1186/s13287-017-0510-9
Zheng H, Zhang B, Chhatbar PY, et al. Mesenchymal Stem Cell Therapy in Stroke : A Systematic Review of Literature in Pre-Clinical and Clinical Research. 2018;27(12):1723-1730. doi:10.1177/0963689718806846
Yeltokova M, Ulyanova O, Askarov M, Chernyshova A, Kozina L. Integral Hematologic Indices in the Evaluation of the Immunologic Reactivity of the Organism in a Patient With Complication of Type 1 Diabetes Mellitus : A Case of Diabetic Retinopathy After Autologous Mesenchymal Stem Cell Transplant. Published online 2019:234-235. doi:10.6002/ect.MESOT2018.P99
Espinosa JML, Mora G, Blanco JF, et al. Intra ? articular injection of two different doses of autologous bone marrow mesenchymal stem cells versus hyaluronic acid in the treatment of knee osteoarthritis : multicenter randomized controlled clinical trial ( phase I / II ). J Transl Med. Published online 2016:1-9. doi:10.1186/s12967-016-0998-2
Fu Y, Yan Y, Qi Y, et al. Impact of Autologous Mesenchymal Stem Cell Infusion on Neuromyelitis Optica Spectrum Disorder : A Pilot , 2-Year Observational Study. 2016;22:677-685. doi:10.1111/cns.12559
Gao F, Chiu SM, Motan DAL, et al. Mesenchymal stem cells and immunomodulation : current status and future prospects. Published online 2016. doi:10.1038/cddis.2015.327
Zhang H, Xue F, Xiao HJ. Ilizarov method in combination with autologous mesenchymal stem cells from iliac crest shows improved outcome in tibial non-union. Saudi J Biol Sci. 2018;25(4):819-825. doi:10.1016/j.sjbs.2016.11.001
Ghoryani M, Shariati-sarabi Z, Tavakkol-afshari J, Ghasemi A. Biomedicine & Pharmacotherapy Amelioration of clinical symptoms of patients with refractory rheumatoid arthritis following treatment with autologous bone marrow-derived mesenchymal stem cells : A successful clinical trial in Iran. Biomed Pharmacother. 2019;109(November 2018):1834-1840. doi:10.1016/j.biopha.2018.11.056
Honmou O, Yamashita T, Morita T, Oshigiri T. Intravenous infusion of auto serum-expanded autologous mesenchymal stem cells in spinal cord injury patients : 13 case series. Clin Neurol Neurosurg. 2021;203(November 2020):106565. doi:10.1016/j.clineuro.2021.106565
Tomkins BA, Rieger AC, a Victoria Florea, MD A, Banerjee MN. Comparison of mesenchymal stem cell efficacy in ischemic versus nonischemic dilated cardiomyopathy. J Am Hear Assoc. 2018;7:1-9. doi:10.1161/JAHA. 117.008460
Tsang KS, Ping C, Ng S, et al. Phase ? / ? randomized controlled trial of autologous bone marrow-derived mesenchymal stem cell therapy for chronic stroke. 2017;9(8):133-143. doi:10.4252/wjsc.v9.i8.133
Vaquero J, Zurita M, Rico MA, et al. Repeated subarachnoid administrations of autologous mesenchymal stromal cells supported in autologous plasma improve quality of life in patients suffering incomplete spinal cord injury. Cytotherapy. 2017;19(3):349-359. doi:10.1016/j.jcyt.2016.12.002
Mesenchymal BM, Trial P, Suk KT, et al. Transplantation With Autologous Bone Marrow-Derived Mesenchymal Stem Cells for Alcoholic Cirrhosis: Phase 2 Trial. 2016;64(6):2185-2197. doi:10.1002/hep.28693
Mehrabani D, Jaberi FM, Zakerinia M. The Healing Effect of Bone Marrow-Derived Stem Cells in Knee Osteoarthritis : A Case Report. Published online 2016:168-174.
Saad A, Dietz AB, Herrmann SMS, et al. Autologous Mesenchymal Stem Cells Increase Cortical Perfusion in Renovascular Disease. Published online 2017:2777-2785. doi:10.1681/ASN.2017020151
Cui GHUA, Wang YY, Li CJUN, Shi CHUI, Wang WEIS. Efficacy of mesenchymal stem cells in treating patients with osteoarthritis of the knee : A meta ? analysis. Published online 2016:3390-3400. doi:10.3892/etm.2016.3791
Kong L, Zheng LZ, Qin L, Ho KKW. Role of mesenchymal stem cells in osteoarthritis treatment. J Orthop Transl. 2017;9:89-103. doi:10.1016/j.jot.2017.03.006
Silvestro S, Bramanti P, Trubiani O, Mazzon E. Stem cells therapy for spinal cord injury: An overview of clinical trials. Int J Mol Sci. 2020;21(2):1-26. doi:10.3390/ijms21020659
DOI: https://doi.org/10.30596/bf.v7i2.9650
DOI (PDF): https://doi.org/10.30596/bf.v7i2.9650.g8669
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JURNAL BULETIN FARMATERA
Gedung Kampus 1 Universitas Muhammadiyah Sumatera Utara (UMSU) Lantai II, Laboratorium Farmakologi dan Terapi Fakultas Kedokteran UMSU Jalan Gedung Arca No. 53 Medan Sumatera Utara Indonesia, Kode Pos 20217.
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