NEUROPROTECTIVE EFFECTS OF COFFEE CHERRY (COFFEA SPP.): A SYSTEMATIC REVIEW OF IN VIVO AND IN VITRO STUDIES

Emni Purwoningsih, Qarina Hasyala Putri, Syafiq Asnawi Zainal Abidin

Abstract


Coffee cherry, the fruit of Coffea spp., has attracted increasing attention as a rich source of bioactive compounds with potential neuroprotective properties. This systematic review aims to evaluate the neuroprotective effects of coffee cherry based on evidence from in vivo and in vitro studies. A comprehensive literature search was conducted using PubMed, Scopus, Web of Science, ScienceDirect, and Google Scholar databases in accordance with the PRISMA 2020 guidelines. Original experimental studies published between 2020 and 2025 that investigated coffee cherry or its derivatives in in vivo or in vitro neurological models were included. The results indicate that coffee cherry exhibits neuroprotective effects primarily through antioxidant and anti-inflammatory mechanisms. Across experimental models, coffee cherry and its bioactive compounds were shown to reduce oxidative stress, attenuate neuroinflammatory responses, protect mitochondrial function, and enhance neuronal survival. In conclusion, coffee cherry demonstrates promising neuroprotective potential based on preclinical evidence from in vivo and in vitro studies; however, further standardized and well-designed studies are required to strengthen the evidence base and support future translational research.


Full Text:

PDF

References


Angeloni, S., Navarini, L., Khamitova, G., Maggi, F., Sagratini, G., & Caprioli, G. (2022). Coffee fruit as a source of bioactive compounds: Antioxidant and anti-inflammatory properties. Food Chemistry, 370, 131042.

Chen, Z., Zhong, C., & Liu, Y. (2023). Oxidative stress in neurodegenerative diseases: Molecular mechanisms and therapeutic perspectives. Frontiers in Molecular Neuroscience, 16, 1189453.

Feigin, V. L., Vos, T., Nichols, E., Owolabi, M. O., Carroll, W. M., Dichgans, M., Murray, C. J. L. (2021). Global burden of neurological disorders, 1990–2019: A systematic analysis. The Lancet Neurology, 20(5), 367–417.

Gauthier, S., Rosa-Neto, P., Morais, J. A., & Webster, C. (2021). World Alzheimer Report 2021: Journey through the diagnosis of dementia. Alzheimer’s & Dementia, 17(11), 1751–1760.

Gómez-Juaristi, M., González-Torres, L., Bravo, L., Vaquero, M. P., Bastida, S., & Sánchez-Muniz, F. J. (2021). Bioavailability and antioxidant activity of coffee by-products. Journal of Agricultural and Food Chemistry, 69(11), 3450–3462.

Hou, Y., Dan, X., Babbar, M., Wei, Y., Hasselbalch, S. G., Croteau, D. L., & Bohr, V. A. (2023). Ageing as a risk factor for neurodegenerative disease. Nature Reviews Neurology, 19(2), 89–107.

Iriondo-DeHond, A., Aparicio García, N., Velázquez Escobar, F., San Andrés, M. I., Sanchez-Fortun, S., Blanch, G. P., Del Castillo, M. D. (2021). Coffee by-products as sustainable ingredients for food and health applications. Trends in Food Science & Technology, 107, 349–364.

Klingel, T., Kremer, J. I., Gottstein, V., Rajcic de Rezende, T., Schwarz, S., & Lachenmeier, D. W. (2020). A review of coffee by-products including coffee cherry and their chemical composition. Food Research International, 137, 109703.

Leng, F., & Edison, P. (2021). Neuroinflammation and microglial activation in Alzheimer’s disease. Frontiers in Aging Neuroscience, 13, 607512.

Martinez-Saez, N., Ullate, M., Martin-Cabrejas, M. A., Martorell, P., Genovés, S., Ramon, D., & Del Castillo, M. D. (2021). Coffee cherry and coffee pulp as potential sources of functional ingredients. Journal of Agricultural and Food Chemistry, 69(43), 12799–12811.

Salehi, B., Sharifi-Rad, J., Capanoglu, E., Adrar, N., Catalkaya, G., Shaheen, S., … Martins, N. (2023). Plant polyphenols: From neuroprotection to therapeutic applications. Phytotherapy Research, 37(2), 482–502. https://doi.org/10.1002/ptr.7640

Vauzour, D., Camprubi-Robles, M., Miquel-Kergoat, S., Andres-Lacueva, C., Banati, D., Barberger-Gateau, P., … Spencer, J. P. E. (2021). Nutrition for the ageing brain: Towards evidence-based recommendations. Nutrients, 13(10), 3415.

Wang, Y., Xu, H., Fu, Q., Ma, R., & Xiang, J. (2022). Protective mechanisms of natural compounds against neurodegenerative diseases. Frontiers in Pharmacology, 13, 947462.

Zhu, Y., Wang, Y., Zhao, B., & Li, J. (2022). Polyphenols and neuroprotection: Molecular mechanisms and therapeutic potential. Oxidative Medicine and Cellular Longevity, 2022, 1–15.




DOI: https://doi.org/10.3059/insis.v0i0.29656

DOI (PDF): https://doi.org/10.3059/insis.v0i0.29656.g15138

Refbacks

  • There are currently no refbacks.