Role of Soluble Heat Shock Proteins 70 in Severity of Dengue Infection

Dr. Nurfadly Zain

Abstract


Objective: to prove the role of soluble HSP 70 in the severity of dengue infection by comparing the level of solubI<fiSP 70 in patients who diagnosed as dengue fever (OF), deng!:]e hemon-ha ic fever (DJ- and I healthy people.
Methods: Thi was a pro pective and longitudinal study, samples were taken by using consecutive sampling with a sample size were 22 OF patients, 20 DHF patients and 20 healthy people as a control group. Soluble HSP 70 in sertUn was measured by an enzyme-linked inununosorbent assay (ELISA).
Results: The soluble I-ISP 70 was significantly increased (p=0.003) in DHF patients (0.33 0.17 ng/ml) compared to in OF patients (0.149 0.19 ng/ml) and control group (0.147 0.37 ng/mJ), but there was not significantly increased (p=0.241) in OF patients compare within control group


Keywords


Soluble HSP70 Dengue fever, Dengue he1mnorhagic fever

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