HbA1c Levels Relate to the Severity of Atherosclerotic Lesions in Coronary Heart Disease Patients with Type 2 Diabetes Mellitus

Faridah Zulfa Rambe, Sheila Dhiene Putri

Abstract


Abstract: Cardiovascular disease is one of the main causes of death in the world. In diabetes mellitus patients who experience hyperglycemia, the risk of coronary heart disease increases 2-4 times. Diabetes mellitus can be diagnosed using HbA1c examination. Coronary heart disease can be diagnosed using a coronary angiography examination, and the results are assessed using the vessel disease score. The design of this research is observational analytic with a cross-sectional approach. The research was conducted in October-December 2023 at RSU. Medan Hajj. The sample for this study was patients with coronary heart disease who had type 2 diabetes mellitus and underwent HbA1c examination and coronary angiography. Data analysis used the Mann-Whitney test. Based on data from RSU. Haji Medan obtained 23 samples, after 18 samples of multi-vessel disease were found with uncontrolled HbA1c levels, and then analysed with a result of 0.027 (p-value <0.05), which means there is a relationship between HbA1c levels and the severity of atherosclerotic lesions in disease patients. Coronary heart disease patients who have type 2 diabetes mellitus. There is a relationship between HbA1c levels and the severity of atherosclerotic lesions in coronary heart disease patients who have type 2 diabetes mellitus.


Keywords


Coronary heart disease, diabetes mellitus type 2, hba1c, angiography

Full Text:

PDF

References


Kementrian Kesehatan RI. Laporan Nasional Riset Kesehatan Dasar Tahun 2018, accessed 21 Juni 2020, available at: https://repository.badankebijakan.kemkes.go.id/id/eprint/3514/

Virani SS, Alonso A, Aparicio HJ, et al. Heart Disease and Statistics-2021 Update A Report from the American Heart Association. Circulation. 2021;143(8): 254-273 doi:10.1161/CIR.0000000000000950

World Health Organization. Cardiovascular diseases (CVDs). 2021,accessed on 30 July 2022, available at: https://www.who.int/news- room/fact- sheets/detail/cardiovascular-diseases-(cvds)

Khan MA, Hashim MJ, Mustafa H, et al. Global Epidemiology of Ischemic Heart Disease: Results from the Global Burden of Disease Study. Cureus. 2020;12(7). doi:10.7759/cureus.9349

Maulida M, Mayasari D, Rahmayani F. Mentariasih Maulida & Diana Mayasari. Pengaruh Rasio Kolesterol Total Terhadap Hight Density Lipoprotein (HDL) Pada Kejadian Stroke Iskemik. Majority. 2018;7(2).

Bachtiar L, Gustaman RA, Maywati S. Faktor Risiko Yang Berhubungan Dengan Kejadian Penyakit Jantung Koroner (PJK) (Analisis Data Sekunder Di Rumah Sakit Umum Daerah Kabupaten Subang). Jurnal Kesehatan Komunikasi Indonesia. 2023;19(1): 52-60

Perkumpulan Endokrinologi Indonesia. Pedoman Pengelolaan dan Pencegahan Diabetes Melitus Tipe 2 Dewasa di Indonesia. Jakarta: Perkeni. 2021

Perhimpunan Dokter Spesialis Karidovaskular Indonesia. Panduan Praktik Klinis dan Clinical Pathway Penyakit Jantung dan Pembuluh Darah. Jakarta: PERKI. 2018

Park GM, Lee CH, Lee SW, et al. Impact of diabetes control on subclinical atherosclerosis: Analysis from coronary computed tomographic angiography registry. Diabetes Metab J. 2019;43: 470-479. doi:10.4093/dmj.2019.0073

Kim M, Bae DH, Lee JH, et al. Impact of multivessel versus single-vessel disease on the association between low diastolic blood pressure and mortality after acute myocardial infarction with revascularization. CardiolJ. 2022;5(3): 2-12. doi:10.5603/cj.a2022.0067

Weissler-Snir A, Gurevitz C, Assali A, et al. Prognosis of STEMI patients with multi-vessel disease undergoing culprit-only PCI without significant residual ischemia on non-invasive stress testing. PLoS One. 2018;10(9): 1-12.doi:10.1371/journal.pone.0138474

Tavares CAF, Rassi CHRE, Fahel MG, et al. Relationship between Glycemic Control and Coronary Artery Severity, Prevalence and Plaque Characteristics by computed Tomography Coronary Angiography in Asymptomatic 2 Diabetic Patients. Int J Cardiovac Imaging. 2018. doi: 0.1007/s10554-016- 0942-9

Rahayu DC, Hakim L, Harefa K. Faktor-Faktor Yang Mempengaruhi Kejadian Penyakit Jantung Koroner Di RSUD Rantau Prapat Tahun 2020. 2021;5(2): 1055-1057

Suciana, Hengky HK, Usman. Analisis Faktor Risiko Penyakit Jantung Koroner pada Penderita Diabetes Melitus Tipe 2 di RSUD Andi Makassau Kota Parepare. Jurnal Ilmiah Manusia dan Kesehatan. 2021;4(2): 254-265

Ruiz GJ, Lerman A, Weisz G, et al. Age- and Gender-related Changes in Plaque Composition in Patients with Acute Coronary Syndrome: The Prospect Study. EuroIntervention. 2020;8(8): 929-938. doi:10.4244/EIJV8I8A142

Amisi WG, Nelwan JE, Kolibu FK. Hubungan Antara Hipertensi Dengan Kejadian Penyakit Jantung Koroner Pada Pasie Yang Berobat Di Rumah Sakit Umum Pusat Prof. Dr. D. Kandou Manado. Kesmas. 2021;7(4).

Noviyanti K, Setiawan EK. Hubungan Profil Lipid dan C-reactive Protein (CRP) dengan Derajat Stenosis Koroner pada Penyakit Jantung Koroner Stabil. Intisari Sains Medis. 2019;10(1):165-168. doi:10.1556/ism.v10i1.332

Mhlaba L, Mpanya D, Tsabedze N. HbA1c control in type 2 diabetes mellitus patients with coronary artery disease: a retrospective study in a tertiary hospital in South Africa. Frontiers in Clinical Diabetes and Healthcare. 2023;4. doi:10.3389/fcdhc.2023.1258792

Chen S, Shen Y, Liu YH, l. Impact of glycemic control on the association of endothelial dysfunction and coronary artery disease in patients with type 2 diabetes mellitus. Cardiovasc Diabetol. 2021;20(64): 1-9. doi:10.1186/s12933-021-01257-y

Lu’lu’ AZ, Khotimah S, Herdianto D. Hubungan Gula Darah Puasa dan Profil Lipid dengan Vessel Disease pada Pasien Penyakit Jantung Koroner. J. Ked. Mulawarman. 2022;9(3): 115-121

Maruhashi T, Higashi Y. Pathophysiological Association between Diabetes Mellitus and Endothelial Dysfunction. Antioxidants. 2021;10(8). doi:10.3390/antiox10081306

Knapp M, Łukaszuk B, Lisowska A, et al. Multivessel Coronary Artery Disease Complicated by Diabetes Mellitus Has a Relatively Small Effect on Endothelial and Lipoprotein Lipases Expression in the Human Coronary Artery Disease. Int J Mol Sci. 2023;24(17). doi:10.3390/ijms241713552

Banovic M, Athithan L, McCann GP. Coronary stenosis and diabetes mellitus: An ominous combination. Diab Vasc Dis Res. 2019;16(4):310-323. doi:10.1177/1479164118820657




DOI (PDF): https://doi.org/10.30596/bf.v11i1.26797.g14295

Refbacks

  • There are currently no refbacks.


JURNAL BULETIN FARMATERA

Gedung Kampus 1 Universitas Muhammadiyah Sumatera Utara (UMSU) Lantai II, Laboratorium Farmakologi dan Terapi Fakultas Kedokteran UMSU Jalan Gedung Arca No. 53 Medan Sumatera Utara Indonesia, Kode Pos 20217.

Contact (WA): 0812-6208-2844

E-mail: farmatera@umsu.ac.id


 
Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Statcounter View My Stats Buletin Farmatera