Administration of Red Mushroom Rice (Angkak) Affects the Increase in Platelet Count in Chloramphenicol-Induced Rats
Abstract
Abstract: Thrombocytopenia is a condition where platelet levels in the blood decrease. The isoflavone and lovastatin content in Angkak has the potential to be an additional therapy to increase the number of platelets. This study aims to determine the effect of Red Mushroom Rice Administration (Angkak) in increasing the Number of Platelets in Chloramphenicol-Induced Rats. This research is experimental research using a pretest and posttest with a control group design. The results of the paired t-test show a significance value of 0.027 < 0.05. This shows that between day 0 and day 12 there are significant differences in each group. The ANOVA test results show a significance value for day 12 of 0.002. The significance value shows a value <0.05. This shows that administering Angkak on day 12 has a significant effect on platelet counts. In this study, the positive control was significantly different from the other groups. This positive control group also showed the lowest average platelet count on day 0. Treatment Group I also showed significantly different results with the highest average platelet count on day 12. Conclusion: From the results of this study, it can be concluded that the administration of boiled water, increasing the doses of 2 g/KgBW, 1 g/KgBW, and 0.5 g/KgBW, had an effect in increasing the number of platelets in male rats induced by chloramphenicol.
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DOI (PDF): https://doi.org/10.30596/bf.v12i2.30451.g15627
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JURNAL BULETIN FARMATERA
Gedung Kampus 1 Universitas Muhammadiyah Sumatera Utara (UMSU) Lantai II, Laboratorium Farmakologi dan Terapi Fakultas Kedokteran UMSU Jalan Gedung Arca No. 53 Medan Sumatera Utara Indonesia, Kode Pos 20217.
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